An excellent opportunity has arisen to join a leading pharmaceutical company as a Senior Translational Scientist.
Our clients Pharmacology & Screening team is dedicated to accelerating the development of new therapies for cancer by leveraging the knowledge around our drug candidates.
Your main responsibilities:
*Works in matrix organization in close collaboration with other Translational Medicine functions (DMPK, Preclinical Safety and Diagnostics/Personalized Medicine) to characterize the pharmacological properties of our drug candidates:
*Represents the Translational Pharmacology function in the Translational Medicine Project Teams;
*May represent the Translational Medicine function in the global Project Teams and lead a Translational Medicine Project Team (core team member).
*Manages laboratory-to-human research in Contract Research Organizations: designs, monitors, and reports the primary and secondary pharmacology studies performed:
*In vitro/in vivo pharmacology compounds selection and profiling, including off target characterization
*Proof of concept in vivo studies - PK/PD
*Mechanism of action studies
*Identification, method development/validation of clinical pharmacodynamic (PDy) biomarkers
*As clinical study team member
*Defines and manages the clinical translational PDy analyses (incl. blood and tissue biomarkers), data analyses and reporting according to GCPs and GCLPs
*Supports and advises the Clinical Research and Development team
*Contributes to the preparation of the pharmacology regulatory documentation (IDB, summaries for IND and IMPD, briefing documentation)
*May participate in interactions with Health Authorities.
*Participates in external scientific communications (publications, poster and oral presentations).
*PhD in relevant expertise area or equivalent in biomedical engineering
*More than 5 years demonstrated experience in Translational Pharmacology Research and drug development in oncology projects
*Experience in the pharma industry a strong asset
*In-depth knowledge in translational research in personalized oncology and basic knowledge of related disciplines including histopathology, bioanalytics, pharmacokinetics and PK/PD
*Knowledge of GCP, GCLP and ICH guidelines; animal welfare regulations; and cancer drug development and regulations
*Very good IT and analytical skills incl. advanced graphical explorations (R statistical software and image analysis, a plus)
*Excellent communication and presentation skills (oral and written)
*Fluent in English
*Project management experience
*Excellent team working skills
*Ability to influence through the matrix, demonstrated assertiveness and impact in communication
Please contact Mark Cussens, Clinical Research Recruiter on
Tel: +44 1727 817623 or email: firstname.lastname@example.org
Tel: +41 4350 86620 or email: email@example.com
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